Novel Neocryptolepine Derivative
Novel Neocryptolepine Derivative latest news, images, analysis about DOI: 10.1016/j.ejphar.2022.175408 Published: 2023/01/05Keywords: AGS cell; Cell cycle; Natural products; Neocryp…Authors: Yunhao MaPage Count: 1
Most Popular News for Novel Neocryptolepine Derivative
CFNC, a neocryptolepine derivative, inhibited the growth of gastric cancer AGS cells by inhibiting PI3K/AKT signaling pathway
DOI: 10.1016/j.ejphar.2022.175408 Published: 2023/01/05Keywords: AGS cell; Cell cycle; Natural products; Neocryp…Authors: Yunhao MaPage Count: 1
Design, Synthesis, and Antifungal Evaluation of Neocryptolepine ...
Jan 29, 2020 · In this study, neocryptolepine and its derivatives (1–49) were designed and synthesized from economical and readily available starting materials. Their structures were …
Searching for new derivatives of neocryptolepine: Synthesis ...
May 6, 2014 · A series of novel amino acid and dipeptide derivatives of neocryptolepine were synthesized and tested for their antimicrobial, antifungal and antiproliferative activity in vitro …
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Research advances in anti-cancer activities and mechanism of …
Dec 13, 2024 · This review summarizes the structures of 228 neocryptolepine derivatives, including 84 neocryptolepine derivatives synthesized by our laboratory, and analyzed the …
Synthesis and structure-activity relationships of novel …
May 11, 2017 · Herein we reported the synthesis of a novel series of neocryptolepine(5-methyl-5H-indolo[2,3-b]quinoline) derivatives containing different substituents at C11 using methyl 1H …
Synthesis and Biological Activity of 2-Chloro-8-methoxy-5-methyl-5
Neocryptolepine was isolated from Cryptolepis sanguinolenta, a traditional endemic African herb, which exerts a wide range of biological activities such as antimalaria, antibacterial, and …
Design and cytotoxic evaluation via apoptotic and antiproliferative ...
Jan 31, 2023 · The current study evaluated the cytotoxic activity of 11 (4-Aminophenylamino)neocryptolepine (APAN), a novel derivative of neocryptolepine, on …
Design, Synthesis and Biological Evaluation of Neocryptolepine ...
Oct 7, 2022 · Therefore, a series of neocryptolepine derivatives were synthesized by the modification of the structure of neocryptolepine, and their cytotoxicity was evaluated. The …
Synthesis of 8-Fluoroneocryptolepine and Evaluation …
Feb 22, 2022 · Our results indicate that 8FNC arrests the AGS cell cycle in the G2/M phase, reduces the mitochondrial membrane potential of AGS cells, and drives the initiation of apoptotic body formation in 8FNC-induced apoptosis. …
Searching for new derivatives of neocryptolepine: synthesis ...
May 6, 2014 · A series of novel amino acid and dipeptide derivatives of neocryptolepine were synthesized and tested for their antimicrobial, antifungal and antiproliferative activity in vitro …
Synthesis and Biological Evaluation of New Amino Acid and …
The syntheses of neocryptolepine derivatives containing an amino acid or a dipeptide at the C-9 position and their evaluation for antitumor activity in vitro and in vivo are reported.
Design, Synthesis, and Antiproliferative Activity of Novel ...
Nov 5, 2022 · A series of novel neocryptolepine-rhodanine hybrids (9a,b, 11a - d, 14, and 16a,b) have been synthesized by combining neocryptolepine core 5 modified at the C-11 position with …
Design, Synthesis and Biological Evaluation of Neocryptolepine …
Oct 7, 2022 · Therefore, a series of neocryptolepine derivatives were synthesized by the modification of the structure of neocryptolepine, and their cytotoxicity was evaluated. The …
Exploring the cytotoxic potential of neocryptolepine derivatives ...
Dec 13, 2024 · This article summarizes the structures of 228 neocryptolepine derivatives, including 84 neocryptolepine derivatives synthesized by our laboratory, and analyzed the …
Design, Synthesis, and Antifungal Evaluation of Cryptolepine ...
Jan 26, 2021 · In the pursuit of further expanding the antifungal spectrum of cryptolepine, ring-opened compound f1 produced better activity with an EC 50 of 3.632 μg/mL against R. solani …
Novel pharmacological approaches to lowering blood pressure …
1 day ago · Hypertension, or high blood pressure (BP), is the leading cause of morbidity and mortality worldwide 1, mostly due to its well-established association with a range of …
Synthesis and Antiplasmodial Activity of Aminoalkylamino …
A series of chloro- and aminoalkylamino-substituted neocryptolepine (5-methyl-5H-indolo[2,3-b]quinoline) derivatives were synthesized and evaluated as antiplasmodial agents. The …